Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | TACR2 | P21452 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774406 | 0.94 | RARB (0.50) | HTR2AKDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL8774481 | 0.94 | NFKB1 (0.44) | HTR2AKDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL8774784 | 0.89 | RAB9A (0.46) | KDM4EALDH1A1HSD17B10MAPTRAB9A | |
| SCHEMBL8775147 | 0.87 | NPC1 (0.47) | HTR2AHSD17B10MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8774858 | 0.85 | MEN1 (0.44) | ALDH1A1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8774557 | 0.85 | RARB (0.57) | HTR2AKDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL8774898 | 0.85 | RARB (0.57) | HTR2AKDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL8774178 | 0.85 | CYP3A4 (0.43) | ALDH1A1HSD17B10MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8774942 | 0.85 | RARB (0.57) | HTR2AKDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL8774709 | 0.85 | RARB (0.57) | HTR2AKDM4EALDH1A1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |