Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD | Q12882 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HBB | P68871 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6512588 | 0.79 | DPYD (0.59) | DPYDMAPTALDH1A1LMNACYP19A1 | |
| SCHEMBL190003 | 0.79 | DPYD (0.62) | DPYDMAPTALDH1A1LMNACYP19A1 | |
| SCHEMBL933037 | 0.79 | DPYD (0.59) | DPYDMAPTALDH1A1LMNACYP19A1 | |
| SCHEMBL6374582 | 0.79 | DPYD (0.59) | DPYDMAPTALDH1A1LMNACYP19A1 | |
| SCHEMBL190377 | 0.79 | DPYD (0.59) | DPYDMAPTALDH1A1LMNACYP19A1 | |
| SCHEMBL190378 | 0.79 | DPYD (0.59) | DPYDMAPTALDH1A1LMNACYP19A1 | |
| SCHEMBL15798473 | 0.79 | DPYD (0.62) | DPYDMAPTALDH1A1LMNACYP19A1 | |
| SCHEMBL6374591 | 0.79 | DPYD (0.59) | DPYDMAPTALDH1A1LMNACYP19A1 | |
| SCHEMBL65892 | 0.79 | DPYD (0.62) | DPYDMAPTALDH1A1LMNACYP19A1 | |
| SCHEMBL8966741 | 0.79 | DPYD (0.59) | DPYDMAPTALDH1A1LMNACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719271-A1 | 5-(1-FLUORO-VINYL)-1H-PYRIMIDINE-2,4-DIONE DERIVATIVES USEFUL AS ANTINEOPLASTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-03 | — | — | EP | claimed |
| WO-1995007917-A1 | 5-(1-FLUORO-VINYL)-1H-PYRIMIDINE-2,4-DIONE DERIVATIVES USEFUL AS ANTINEOPLASTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-23 | — | — | WO | claimed |
| EP-0719271-B1 | 5-(1-FLUORO-VINYL)-1H-PYRIMIDINE-2,4-DIONE DERIVATIVES USEFUL AS ANTINEOPLASTIC AGENTS | MERRELL PHARMA INC (US) | 1997-11-26 | — | — | EP | disclosed |
| EP-0719271-A1 | 5-(1-FLUORO-VINYL)-1H-PYRIMIDINE-2,4-DIONE DERIVATIVES USEFUL AS ANTINEOPLASTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-03 | — | — | EP | disclosed |
| WO-1995007917-A1 | 5-(1-FLUORO-VINYL)-1H-PYRIMIDINE-2,4-DIONE DERIVATIVES USEFUL AS ANTINEOPLASTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-23 | — | — | WO | disclosed |