Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 12/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NAAA | Q02083 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9426614 | 0.78 | LMNA (0.62) | HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL4026832 | 0.78 | ALDH1A1 (0.67) | EPHX1HTTALDH1A1 | |
| SCHEMBL4024825 | 0.78 | ALDH1A1 (0.67) | EPHX1HTTALDH1A1 | |
| SCHEMBL4023576 | 0.76 | ALDH1A1 (0.69) | EPHX1HTTALDH1A1 | |
| SCHEMBL6442708 | 0.75 | EPHX1 (0.73) | EPHX2EPHX1HTTALDH1A1NAAA | |
| SCHEMBL8777922 | 0.74 | EPHX2 (0.66) | EPHX2EPHX1HTTALDH1A1HDAC1 | |
| SCHEMBL8777838 | 0.74 | EPHX1 (0.55) | EPHX2EPHX1HTTALDH1A1CDK2 | |
| SCHEMBL8777984 | 0.73 | EPHX2 (0.55) | EPHX2EPHX1HTTALDH1A1 | |
| SCHEMBL18274878 | 0.72 | SMN1; SMN2 (0.59) | EPHX2EPHX1HTTALDH1A1CDK2 | |
| SCHEMBL9426618 | 0.72 | HTT (0.51) | HTTALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |