SCHEMBL8777904

SCHEMBL8777904

COC(=O)Oc1ccc2c(c1N)C(=O)c1ccccc1C2=O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.60
MAPT P10636 8/20 0.55
MEN1 O00255 7/20 0.55
KMT2A Q03164 7/20 0.55
ALDH1A1 P00352 6/20 0.55
MAPK1 P28482 6/20 0.55
SMN1; SMN2 Q16637 5/20 0.55
RAB9A P51151 4/20 0.55
POLB P06746 4/20 0.55
NPC1 O15118 3/20 0.55
THRB P10828 3/20 0.55
L3MBTL1 Q9Y468 2/20 0.55
LMNA P02545 2/20 0.55
NPSR1 Q6W5P4 2/20 0.55
TDP1 Q9NUW8 2/20 0.55
CYP3A4 P08684 2/20 0.55
MCL1 Q07820 2/20 0.55
TSHR P16473 1/20 0.55
CASP3 P42574 1/20 0.55
HBB P68871 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4397430 0.84 ADORA2A (0.68) ADORA2AMAPTMEN1KMT2AALDH1A1
SCHEMBL8777916 0.84 ADORA2A (0.63) ADORA2AMAPTMEN1KMT2AALDH1A1
SCHEMBL9751849 0.84 RAB9A (0.68) ADORA2AMAPTMEN1KMT2AALDH1A1
SCHEMBL9509808 0.83 ADORA2A (0.61) ADORA2AMAPTMEN1KMT2AALDH1A1
SCHEMBL28341314 0.83 ELANE (0.57) ADORA2AMAPTMEN1KMT2AALDH1A1
SCHEMBL11023123 0.82 MEN1 (0.55) ADORA2AMAPTMEN1KMT2AALDH1A1
SCHEMBL2460415 0.80 ELANE (0.54) MAPTMEN1KMT2AALDH1A1MAPK1
SCHEMBL8941856 0.79 MAPT (0.71) ADORA2AMAPTMEN1KMT2AALDH1A1
SCHEMBL11845702 0.76 MAPT (0.53) ADORA2AMAPTMEN1KMT2AALDH1A1
Methoxymethane SCHEMBL11741879 0.76 MAOA (0.86) ADORA2AMAPTMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0585873-B1 Method of preparing disazo pigments CLARIANT GMBH (DE) 1997-12-29 EP disclosed
EP-0518909-B1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE HOECHST AG (DE) 1994-05-25 EP disclosed
EP-0585873-A1 Method of preparing disazo pigments HOECHST AKTIENGESELLSCHAFT (DE) 1994-03-09 EP disclosed
EP-0518909-A1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE. HOECHST AG (DE) 1992-12-23 EP disclosed
EP-0316649-B1 WATER INSOLUBLE AZO COLOURING AGENTS, THEIR PREPARATION AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1992-07-22 EP disclosed
WO-1991013941-A1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1991-09-19 WO disclosed
EP-0316649-A2 Water insoluble azo colouring agents, their preparation and use HOECHST AKTIENGESELLSCHAFT (DE) 1989-05-24 EP disclosed
EP-0008627-B1 QUINAZOLINE DERIVATIVES, AZO DYES DERIVED FROM THE QUINAZOLINES AND THEIR USE AS PIGMENTS BAYER AG (DE) 1984-10-03 EP disclosed
EP-0043937-B1 ANTHRAQUINONE-AZO COMPOUNDS, THEIR PREPARATION AND THEIR USE BAYER AG (DE) 1984-09-19 EP disclosed
EP-0058866-B1 ANTHRAQUINONE-AZO COMPOUNDS, THEIR PREPARATION AND USE BAYER AG (DE) 1984-07-18 EP disclosed
EP-0023666-B1 ANTHRAQUINONE-AZOMETHINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AS WELL AS A PROCESS FOR PIGMENTING ORGANIC MACROMOLECULAR MATERIALS BAYER AG (DE) 1982-10-13 EP disclosed
EP-0058866-A1 Anthraquinone-azo compounds, their preparation and use BAYER AG (DE) 1982-09-01 EP disclosed
EP-0023648-B1 ANTHRAQUINONE-AZOMETHINE COMPOUNDS, PROCESS FOR THEIR PREPARATION; PROCESS FOR DYEING SYNTHETIC FIBRE MATERIALS AS WELL AS FOR PIGMENTING ORGANIC MACROMOLECULAR MATERIALS BAYER AG (DE) 1982-06-23 EP disclosed
EP-0043937-A2 Anthraquinone-azo compounds, their preparation and their use BAYER AG (DE) 1982-01-20 EP disclosed
EP-0023617-A1 Anthraquinone-azo compounds, process for their preparation and their use as pigments BAYER AG (DE) 1981-02-11 EP disclosed
EP-0023666-A1 Anthraquinone-azomethine compounds, process for their preparation as well as a process for pigmenting organic macromolecular materials BAYER AG (DE) 1981-02-11 EP disclosed
EP-0023648-A1 Anthraquinone-azomethine compounds, process for their preparation; process for dyeing synthetic fibre materials as well as for pigmenting organic macromolecular materials BAYER AG (DE) 1981-02-11 EP disclosed
EP-0018538-A2 Anthraquinone derivatives, process for their preparation, process for the pigmentation of organic macromolecular materials and pigmented organic macromolecular material BAYER AG (DE) 1980-11-12 EP disclosed
EP-0008627-A2 Quinazoline derivatives, azo dyes derived from the quinazolines and their use as pigments BAYER AG (DE) 1980-03-19 EP disclosed
EP-0008063-A1 Azomethine derivatives of anthraquinones, methods for their preparation, their use in the pigmentation of organic macromolecular compounds and the materials thus obtained BAYER AG (DE) 1980-02-20 EP disclosed