Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28341314 | 0.93 | ELANE (0.57) | ELANEMEN1KMT2AKDM4EHPGD | |
| SCHEMBL6036890 | 0.83 | ALDH1A1 (0.51) | ELANEMEN1KMT2AKDM4EHPGD | |
| SCHEMBL31435387 | 0.82 | MAPT (0.70) | ELANEMEN1KMT2AKDM4EHPGD | |
| SCHEMBL11039554 | 0.81 | ELANE (0.55) | ELANEMEN1KMT2AKDM4EHPGD | |
| SCHEMBL6220950 | 0.81 | KEAP1 (0.49) | ELANEMEN1KMT2AKDM4EHPGD | |
| SCHEMBL6254697 | 0.80 | KDM4E (0.63) | MEN1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL8777904 | 0.80 | ADORA2A (0.60) | ELANEMEN1KMT2AKDM4EHPGD | |
| SCHEMBL11102131 | 0.80 | ELANE (0.53) | ELANEMEN1KMT2AKDM4EHPGD | |
| SCHEMBL7550657 | 0.79 | CES1 (0.46) | ELANEMEN1KMT2AKDM4EHPGD | |
| SCHEMBL9279787 | 0.79 | TTR (0.77) | ELANEMEN1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035419-B1 | 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS | BAYER IP GMBH (DE) | 2016-06-22 | — | — | EP | disclosed |
| EP-2029591-B1 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF | Bayer Pharma AG (DE) | 2011-09-07 | — | — | EP | disclosed |
| EP-2035419-A1 | 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS | Bayer HealthCare AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| EP-2029591-A1 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF | Bayer HealthCare AG (DE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140934-A1 | SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007140894-A1 | 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS | BAYER HEALTHCARE AG (DE) | 2007-12-13 | — | — | WO | disclosed |
| WO-2005087740-A1 | FLUORENONE 1, 4,-DIHYDROPYRIDIN DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-09-22 | — | — | WO | disclosed |