Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9089590 | 0.85 | PTGER4 (0.49) | PTGER4PTGER2SIRT2SIRT1HDAC1 | |
| SCHEMBL4728356 | 0.83 | MAPT (0.51) | PTGER4PTGER2SIRT2SIRT1HDAC1 | |
| SCHEMBL5082657 | 0.78 | PTGER4 (0.48) | PTGER4PTGER2SIRT2SIRT1HDAC1 | |
| SCHEMBL8778025 | 0.77 | PTGER4 (0.52) | PTGER4PTGER2MAPTALDH1A1 | |
| SCHEMBL8777876 | 0.77 | ALOX5 (0.51) | PTGER4PTGER2SIRT2SIRT1HDAC1 | |
| SCHEMBL8778078 | 0.75 | PTGER4 (0.46) | PTGER4PTGER2SIRT2SIRT1HDAC1 | |
| SCHEMBL9598300 | 0.74 | HDAC1 (0.48) | PTGER4PTGER2SIRT2SIRT1HDAC1 | |
| SCHEMBL9198265 | 0.73 | HDAC1 (0.51) | PTGER4PTGER2SIRT2SIRT1HDAC1 | |
| SCHEMBL9030409 | 0.73 | HDAC1 (0.53) | PTGER4PTGER2SIRT2SIRT1HDAC1 | |
| SCHEMBL9088952 | 0.73 | PTGER4 (0.51) | PTGER4PTGER2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651743-B1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-12-17 | — | — | EP | disclosed |