Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777876 | 0.84 | ALOX5 (0.51) | PTGER4PTGER2SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL29572755 | 0.80 | SIGMAR1 (0.57) | PTGER4PTGER2SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL5661589 | 0.80 | SIGMAR1 (0.57) | PTGER4PTGER2SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL9204868 | 0.77 | ADRB3 (0.59) | KDM4EALDH1A1HDAC1HDAC6ADRB2 | |
| SCHEMBL8815909 | 0.76 | HDAC1 (0.56) | SIGMAR1ALDH1A1HDAC1HDAC6ADRB2 | |
| SCHEMBL11045005 | 0.76 | HDAC1 (0.48) | PTGER4PTGER2SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL4728356 | 0.75 | MAPT (0.51) | PTGER4PTGER2ALDH1A1HDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL10636985 | 0.75 | HDAC1 (0.47) | PTGER4PTGER2SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL9089590 | 0.75 | PTGER4 (0.49) | PTGER4PTGER2KDM4EALDH1A1HDAC1 | |
| SCHEMBL8778079 | 0.75 | PTGER4 (0.49) | PTGER4PTGER2KDM4EALDH1A1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651743-B1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5541218-A | Indolinyl N-hydroxyurea and N-hydroxamic acid derivatives as lipoxygenase inhibitors | PFIZER INC. (US) | 1996-07-30 | — | — | US | disclosed |
| WO-1994002459-A1 | INDOLINYL N-HYDROZYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-02-03 | — | — | WO | disclosed |