Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8778025 | 0.90 | PTGER4 (0.52) | MAPTPTGER4PTGER2LMNATP53 | |
| SCHEMBL8778095 | 0.89 | FFAR1 (0.47) | MAPTLMNATP53GAAALDH1A1 | |
| SCHEMBL8778007 | 0.86 | LMNA (0.50) | LMNATP53THRBALDH1A1 | |
| SCHEMBL5082657 | 0.83 | PTGER4 (0.48) | MAPTPTGER4PTGER2LMNAHDAC1 | |
| SCHEMBL8778079 | 0.83 | PTGER4 (0.49) | MAPTPTGER4PTGER2HDAC1HDAC6 | |
| SCHEMBL8777898 | 0.82 | MAPT (0.51) | MAPTPTGER4PTGER2LMNAMEN1 | |
| SCHEMBL8777919 | 0.82 | KEAP1 (0.49) | PTGER4PTGER2HDAC1HDAC6SIRT2 | |
| SCHEMBL16494249 | 0.81 | ACHE (0.55) | MAPTLMNAHDAC1HDAC6TP53 | |
| SCHEMBL30104666 | 0.80 | ALDH1A1 (0.68) | LMNAMEN1KMT2AALDH1A1HTT | |
| SCHEMBL8245692 | 0.80 | ALDH1A1 (0.68) | LMNAMEN1KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |
| EP-0651743-B1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-12-17 | — | — | EP | disclosed |