SCHEMBL8778128

SCHEMBL8778128

Cc1ccc(C(=O)ON(C(=O)c2ccccc2)C(=O)c2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.53
CES1 P23141 1/20 0.53
NPC1 O15118 4/20 0.53
RAB9A P51151 4/20 0.53
KMT2A Q03164 2/20 0.49
MEN1 O00255 1/20 0.49
TDP1 Q9NUW8 1/20 0.48
ALDH1A1 P00352 4/20 0.46
TSHR P16473 1/20 0.46
LMNA P02545 2/20 0.45
POLB P06746 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.44
F2 P00734 1/20 0.44
CCR6 P51684 1/20 0.43
MAPT P10636 2/20 0.42
AKR1C3 P42330 1/20 0.42
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8778149 0.93 TDP1 (0.55) CES2CES1NPC1RAB9AKMT2A
SCHEMBL8778288 0.89 LMNA (0.54) CES2CES1KMT2ATDP1ALDH1A1
SCHEMBL10938066 0.79 LMNA (0.47) NPC1RAB9AKMT2AMEN1TDP1
SCHEMBL14354319 0.78 TDP1 (0.55) CES2CES1NPC1RAB9AKMT2A
SCHEMBL6554993 0.77 LMNA (0.74) CES2CES1NPC1RAB9AKMT2A
SCHEMBL775484 0.77 CES2 (0.65) CES2CES1NPC1RAB9AKMT2A
SCHEMBL8778267 0.76 TSHR (0.54) CES2CES1KMT2ATDP1ALDH1A1
SCHEMBL8778253 0.76 ELANE (0.46) CES2CES1ALDH1A1TSHRLMNA
SCHEMBL28171829 0.76 CES2 (0.63) CES2CES1NPC1RAB9AKMT2A
Acetic Acid SCHEMBL776224 0.74 CES2 (0.61) CES2CES1NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0576622-B1 LITHOGRAPHIC PRINTING PLATES EASTMAN KODAK CO (US) 1997-11-05 EP disclosed
EP-0576622-A1 LITHOGRAPHIC PRINTING PLATES EASTMAN KODAK COMPANY (US) 1994-01-05 EP disclosed
WO-1992017821-A1 LITHOGRAPHIC PRINTING PLATES EASTMAN KODAK COMPANY (US) 1992-10-15 WO disclosed
US-5141839-A LITHOGRAPHIC PRINTING PLATES HAVING A RADIATION-SENSITIVE LAYER COMPRISING A PHOTOCROSSLINKABLE POLYMER, A LEUCO DYE, A PHOTOOXIDANT AND A HETEROAROMATIC AMINE N-OXIDE EASTMAN KODAK COMPANY (US) 1992-08-25 US disclosed
US-5141842-A Negative working lithography printing plates EASTMAN KODAK COMPANY (US) 1992-08-25 US disclosed