Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 12/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874812 | 0.90 | GPR139 (0.46) | GPR139KDM4EKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL873568 | 0.88 | GPR139 (0.44) | GPR139 | |
| SCHEMBL877706 | 0.86 | MMP2 (0.45) | GPR139KDM4EKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL874247 | 0.84 | GPR139 (0.44) | GPR139KMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL877229 | 0.83 | GPR139 (0.51) | GPR139SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL874810 | 0.82 | GPR139 (0.52) | GPR139KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL877441 | 0.81 | GPR139 (0.44) | GPR139KDM4EKMT2ANPSR1 | |
| SCHEMBL876956 | 0.81 | GPR139 (0.43) | GPR139SMN1; SMN2LMNA | |
| SCHEMBL876636 | 0.80 | KMT2A (0.52) | GPR139KDM4EKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL874163 | 0.80 | GPR139 (0.45) | GPR139KDM4EKMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619179-A1 | MATRIX METALLOPROTEINASE INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038944-A1 | MATRIX METALLOPROTEINASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-03-29 | — | — | WO | disclosed |