Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CBS | P35520 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463046 | 0.91 | LMNA (0.72) | POLBMEN1KMT2ALMNANPC1 | |
| SCHEMBL7276663 | 0.82 | LMNA (0.63) | MEN1KMT2ALMNARAB9ACYP2C9 | |
| SCHEMBL6324425 | 0.82 | LMNA (0.56) | MEN1KMT2ALMNACYP2C9CA1 | |
| SCHEMBL8418023 | 0.81 | LMNA (0.70) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL6326710 | 0.80 | RAB9A (0.62) | POLBMEN1KMT2ALMNANPC1 | |
| SCHEMBL4749812 | 0.79 | NPC1 (0.80) | POLBMEN1KMT2ALMNAHPSE | |
| SCHEMBL6326204 | 0.79 | LMNA (0.67) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL6326162 | 0.79 | FLT1 (0.54) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL9068784 | 0.78 | FLT1 (0.58) | MEN1KMT2ALMNACYP2C9CA1 | |
| SCHEMBL7285851 | 0.78 | FLT1 (0.58) | MEN1KMT2ALMNACYP2C9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787717-A1 | Substituted diaryl dicarboxylic acid diguanidines, process for their preparation, their use as inhibitors of the Na+/H+ exchange as well as medicament or diagnostic agent containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-08-06 | — | — | EP | disclosed |