Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | GALR1 | P47211 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | AGER | Q15109 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSH | P09668 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | CIT | O14578 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779203 | 0.97 | OPRK1 (0.37) | OPRK1FAAHCTSKCTSLCTSB | |
| SCHEMBL8779263 | 0.97 | OPRK1 (0.37) | OPRK1FAAHCTSKCTSLCTSB | |
| SCHEMBL8779075 | 0.95 | OPRK1 (0.41) | PPARGOPRK1CITCTSCOPRM1 | |
| SCHEMBL8779351 | 0.91 | OPRK1 (0.40) | OPRK1POLBCITCTSCOPRM1 | |
| SCHEMBL8779204 | 0.87 | KDM4E (0.39) | OPRK1LTA4HCITCTSCOPRD1 | |
| SCHEMBL8779164 | 0.87 | KDM4E (0.39) | OPRK1LTA4HCITCTSCOPRD1 | |
| SCHEMBL8779188 | 0.86 | CTSC (0.37) | OPRK1CITCTSCOPRM1OPRD1 | |
| SCHEMBL8779157 | 0.85 | XIAP (0.40) | FAAHXIAP | |
| SCHEMBL8885111 | 0.85 | POLB (0.40) | GALR1OPRK1POLBTSHRAGER | |
| SCHEMBL8779165 | 0.82 | XIAP (0.38) | OPRK1RENXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |