Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.36 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779180 | 0.95 | PTGES (0.38) | OPRK1PPARGCTSCCITALPI | |
| SCHEMBL8779263 | 0.94 | OPRK1 (0.37) | OPRK1MAPTCTSCCITCYP3A4 | |
| SCHEMBL8779203 | 0.94 | OPRK1 (0.37) | OPRK1MAPTCTSCCITCYP3A4 | |
| SCHEMBL8779351 | 0.92 | OPRK1 (0.40) | OPRK1CTSCCITALPIPKM | |
| SCHEMBL8779164 | 0.88 | KDM4E (0.39) | OPRK1CTSCCITALPIPKM | |
| SCHEMBL8779204 | 0.88 | KDM4E (0.39) | OPRK1CTSCCITALPIPKM | |
| SCHEMBL8779188 | 0.87 | CTSC (0.37) | OPRK1CTSCCITALPIPKM | |
| SCHEMBL8779136 | 0.85 | IKBKB (0.37) | PPARGMAPTXIAPALDH1A1SLC15A1 | |
| SCHEMBL8885435 | 0.84 | OPRK1 (0.43) | OPRK1PPARGMAPTCTSCCIT | |
| SCHEMBL8779198 | 0.80 | LTA4H (0.46) | MAPTXIAPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |