Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779134 | 0.91 | CARM1 (0.38) | KDM4EL3MBTL1ALDH1A1MMP2LMNA | |
| SCHEMBL8779153 | 0.90 | CARM1 (0.40) | KDM4EL3MBTL1MEN1ALDH1A1KMT2A | |
| SCHEMBL8779198 | 0.89 | LTA4H (0.46) | KDM4EL3MBTL1ALDH1A1SMN1; SMN2CYP2C9 | |
| SCHEMBL8779316 | 0.88 | MME (0.39) | KDM5APPARGMAOB | |
| SCHEMBL8779265 | 0.85 | TRPV1 (0.38) | MMP2PPARGLTA4HMRGPRX4 | |
| SCHEMBL8779168 | 0.84 | SMN1; SMN2 (0.40) | L3MBTL1MEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL8779212 | 0.83 | HPGD (0.38) | KDM4EL3MBTL1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL8779176 | 0.83 | HPGD (0.38) | KDM4EL3MBTL1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL8882950 | 0.83 | KMT2A (0.41) | KDM4EL3MBTL1MEN1ALDH1A1KMT2A | |
| SCHEMBL8779292 | 0.82 | CARM1 (0.35) | SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |