Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779302 | 0.90 | PLAU (0.36) | SMN1; SMN2ALDH1A1KMT2APPIALMNA | |
| SCHEMBL8779285 | 0.89 | KDM4E (0.40) | SMN1; SMN2L3MBTL1MEN1ALDH1A1KMT2A | |
| SCHEMBL8779406 | 0.89 | LTA4H (0.44) | SMN1; SMN2L3MBTL1PPIA | |
| SCHEMBL8779246 | 0.87 | MAOB (0.43) | ALDH1A1MAOBPPIA | |
| SCHEMBL8786060 | 0.85 | PPIA (0.46) | SMN1; SMN2L3MBTL1MEN1ALDH1A1KMT2A | |
| SCHEMBL8779331 | 0.84 | MMP1 (0.41) | SMN1; SMN2MEN1KMT2AMAOB | |
| SCHEMBL8779192 | 0.84 | KDM4E (0.39) | SMN1; SMN2L3MBTL1MEN1ALDH1A1KMT2A | |
| SCHEMBL8880773 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1MEN1ALDH1A1KMT2A | |
| SCHEMBL8779326 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2KMT2ALMNAHPGD | |
| SCHEMBL8779187 | 0.81 | MRGPRX4 (0.37) | L3MBTL1ALDH1A1MAOBPPIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |