Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779138 | 0.90 | SMN1; SMN2 (0.39) | SMN1; SMN2KMT2AKDM4ELMNA | |
| SCHEMBL8779087 | 0.89 | IKBKB (0.34) | SMN1; SMN2ALDH1A1GRM4L3MBTL1KMT2A | |
| SCHEMBL8779241 | 0.89 | LMNA (0.40) | SMN1; SMN2KMT2ALMNA | |
| SCHEMBL8779273 | 0.89 | IKBKB (0.38) | SMN1; SMN2ALDH1A1CARM1LMNA | |
| SCHEMBL8779326 | 0.88 | SMN1; SMN2 (0.39) | SMN1; SMN2KMT2ACARM1LMNA | |
| SCHEMBL8779257 | 0.88 | LMNA (0.41) | SMN1; SMN2KMT2ALMNA | |
| SCHEMBL8779253 | 0.83 | HTT (0.39) | KDM4E | |
| SCHEMBL8785579 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1L3MBTL1NCF1RAB9A | |
| SCHEMBL8779250 | 0.82 | MEN1 (0.42) | SMN1; SMN2ALDH1A1L3MBTL1RAB9AKMT2A | |
| SCHEMBL8882636 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1GRM4L3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |