Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779406 | 0.86 | LTA4H (0.44) | L3MBTL1RAB9ANPC1SMN1; SMN2PARP10 | |
| SCHEMBL8779273 | 0.86 | IKBKB (0.38) | ALDH1A1TSHRNPC1SMN1; SMN2LMNA | |
| SCHEMBL8785926 | 0.85 | KMT2A (0.40) | MEN1KMT2AALDH1A1TSHRMAPK1 | |
| SCHEMBL8779138 | 0.85 | SMN1; SMN2 (0.39) | KMT2ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL8779092 | 0.84 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1TSHRMAPK1 | |
| SCHEMBL8779162 | 0.84 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1TSHRMAPK1 | |
| SCHEMBL8779241 | 0.84 | LMNA (0.40) | MEN1KMT2ANPC1SMN1; SMN2LMNA | |
| SCHEMBL8779087 | 0.84 | IKBKB (0.34) | MEN1KMT2AALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8779326 | 0.83 | SMN1; SMN2 (0.39) | KMT2ASMN1; SMN2LMNAGAAHPGD | |
| SCHEMBL8779257 | 0.83 | LMNA (0.41) | MEN1KMT2ANPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |