Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779138 | 0.94 | SMN1; SMN2 (0.39) | MAPTHSD17B10LMNAHPGDSMN1; SMN2 | |
| SCHEMBL8779241 | 0.93 | LMNA (0.40) | MAPTLMNASMN1; SMN2CYP2C19FAAH | |
| SCHEMBL8779257 | 0.92 | LMNA (0.41) | MAPTLMNASMN1; SMN2CYP2C19FAAH | |
| SCHEMBL8779326 | 0.90 | SMN1; SMN2 (0.39) | IKBKBLMNAHPGDCARM1GRM5 | |
| SCHEMBL8779277 | 0.89 | SMN1; SMN2 (0.35) | LMNACARM1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8779087 | 0.88 | IKBKB (0.34) | IKBKBLMNAHPGDCARM1SMN1; SMN2 | |
| SCHEMBL8779253 | 0.87 | HTT (0.39) | HTTGAAACACB | |
| SCHEMBL8779250 | 0.86 | MEN1 (0.42) | MAPTLMNAHPGDTSHRSMN1; SMN2 | |
| SCHEMBL8779284 | 0.85 | NFKB1 (0.32) | CARM1 | |
| SCHEMBL8779122 | 0.84 | MAPT (0.33) | MAPTHPGDCARM1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |