Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779273 | 0.90 | IKBKB (0.38) | SMN1; SMN2HPGDIKBKBLMNAACACB | |
| SCHEMBL8779138 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDLMNAKMT2A | |
| SCHEMBL8779277 | 0.88 | SMN1; SMN2 (0.35) | SMN1; SMN2LMNAKMT2ACARM1 | |
| SCHEMBL8779241 | 0.88 | LMNA (0.40) | SMN1; SMN2LMNAKMT2A | |
| SCHEMBL8779284 | 0.87 | NFKB1 (0.32) | CARM1 | |
| SCHEMBL8779257 | 0.87 | LMNA (0.41) | SMN1; SMN2LMNAKMT2A | |
| SCHEMBL8779122 | 0.86 | MAPT (0.33) | SMN1; SMN2HPGDACACBGAACARM1 | |
| SCHEMBL8779087 | 0.85 | IKBKB (0.34) | SMN1; SMN2HPGDIKBKBLMNAACACB | |
| SCHEMBL8779283 | 0.85 | ALDH1A1 (0.35) | — | |
| SCHEMBL8779253 | 0.84 | HTT (0.39) | ACACBGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |