Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.43 |
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 3/20 | 0.35 |
| ▸ | YES1 | P07947 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779229 | 0.90 | IRAK4 (0.40) | IRAK4ACACB | |
| SCHEMBL8779243 | 0.90 | PPARG (0.38) | IRAK4ACACBLMNANFE2L2 | |
| SCHEMBL8779191 | 0.89 | IRAK4 (0.38) | IRAK4ACACBPARP15PARP10 | |
| SCHEMBL8779259 | 0.87 | IRAK4 (0.37) | IRAK4ACACBLMNA | |
| SCHEMBL8779175 | 0.85 | ACACB (0.41) | IRAK4ACACBPDE4APDE4BPDE4C | |
| SCHEMBL8779225 | 0.84 | PARP15 (0.40) | IRAK4ACACBPARP15PARP10 | |
| SCHEMBL8881605 | 0.83 | IRAK4 (0.44) | IRAK4ACACBPDE4APDE4BPDE4C | |
| SCHEMBL8779212 | 0.82 | HPGD (0.38) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8779176 | 0.82 | HPGD (0.38) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8779418 | 0.82 | PPARG (0.36) | IRAK4ACACBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |