Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | LNPEP | Q9UIQ6 | 6/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779418 | 0.92 | PPARG (0.36) | PPARGKITPDGFRALNPEPMCHR1 | |
| SCHEMBL8779239 | 0.91 | LNPEP (0.40) | PPARGKITPDGFRALNPEP | |
| SCHEMBL8779428 | 0.90 | IRAK4 (0.43) | LMNANFE2L2ACACBIRAK4 | |
| SCHEMBL8779390 | 0.85 | NFE2L2 (0.38) | PPARGKITPDGFRALNPEPMCHR1 | |
| SCHEMBL8881924 | 0.84 | LNPEP (0.38) | PPARGKITPDGFRALNPEPMCHR1 | |
| SCHEMBL8779175 | 0.84 | ACACB (0.41) | LNPEPACACBIRAK4 | |
| SCHEMBL8779325 | 0.83 | IKBKB (0.37) | PPARGNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8779136 | 0.83 | IKBKB (0.37) | PPARGNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8779103 | 0.82 | PPARG (0.38) | PPARGMCHR1NPC1SCN9ANFE2L2 | |
| SCHEMBL8779157 | 0.82 | XIAP (0.40) | NPC1SMN1; SMN2LMNAACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |