Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.43 |
| ▸ | ITGAV | P06756 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 3/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687293 | 0.88 | EGLN1 (0.43) | AAK1CASP1TYRNOS1IDO1 | |
| SCHEMBL8779925 | 0.87 | HDAC3 (0.48) | AAK1ITGB3ITGAVCASP1NOS1 | |
| SCHEMBL8779881 | 0.87 | HDAC3 (0.48) | AAK1ITGB3ITGAVCASP1NOS1 | |
| SCHEMBL8779928 | 0.76 | ALDH1A1 (0.41) | AAK1 | |
| SCHEMBL4935704 | 0.75 | PTPN1 (0.49) | CTSK | |
| SCHEMBL4935716 | 0.75 | PTPN1 (0.49) | CTSK | |
| SCHEMBL19227539 | 0.72 | ALDH1A1 (0.57) | CASP1CTSK | |
| SCHEMBL7419324 | 0.72 | CASP1 (0.54) | CASP1CTSKIDO1 | |
| SCHEMBL7419321 | 0.72 | CASP1 (0.54) | CASP1CTSKIDO1 | |
| SCHEMBL4280669 | 0.72 | CASP1 (0.67) | CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539057-B1 | Benzimidazole phosphono-amino acids | AMERICAN HOME PROD (US) | 1997-07-16 | — | — | EP | disclosed |
| EP-0539057-A1 | Benzimidazole phosphono-amino acids | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5124319-A | Administering for treatment of neuropathological disorders induced by overstimulation of excitatory amino acid receptors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-06-23 | — | — | US | disclosed |