Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | C1S | P09871 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035708 | 0.81 | CES2 (0.55) | PARP1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL4869301 | 0.81 | CA12 (0.50) | PARP1ALDH1A1 | |
| SCHEMBL11756446 | 0.81 | TP53 (0.56) | MAPTTP53NPC1RAB9A | |
| SCHEMBL1276988 | 0.80 | ALDH1A1 (0.41) | ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL28415551 | 0.79 | CES2 (0.66) | ALDH1A1MAPTGAATP53MEN1 | |
| SCHEMBL1277041 | 0.79 | PARP1 (0.50) | PARP1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL339923 | 0.79 | ERCC5 (0.58) | PARP1ALDH1A1L3MBTL1KMT2AALOX5 | |
| SCHEMBL8980284 | 0.79 | PBRM1 (0.49) | ALDH1A1MAPTGAATP53MEN1 | |
| SCHEMBL105102 | 0.78 | GSK3B (0.55) | MAPTMEN1KMT2ANPC1HPGD | |
| SCHEMBL8779987 | 0.78 | ERCC5 (0.61) | ALDH1A1MAPTGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108947924-B | Preparation method and application of dihydroisoxazole benzophenone derivative and dihydroisoxazole benzophenone derivative | 石河子大学 | 2022-05-10 | — | — | CN | disclosed |
| CN-102898374-B | A kind of preparation method of 1H-indazole analog derivative | SHANGHAI BEPHARM CO., LTD. (CN) | 2016-03-23 | — | — | CN | disclosed |
| CN-102898374-A | Method for preparing 1H-indazole derivative | BEPHARM LTD | 2013-01-30 | — | — | CN | disclosed |
| US-7169797-B2 | Protein-tyrosine phosphatase inhibitors and uses thereof | ABBOTT LABORATORIES (US) | 2007-01-30 | — | — | US | disclosed |
| US-20040214870-A1 | Controlling gene expression; antidiabetic agents; insulin resistance; autoimmune disease; 5-(3-((1E)-3-(3-hydroxy-2-(methoxycarbonyl)phenoxy)prop-1-enyl)phenyl)isoxazole-3-carboxylic acid | ABBVIE INC. | 2004-10-28 | — | — | US | disclosed |
| US-20040167188-A1 | Controlling gene expression; antidiabetic agents; insulin resistance; autoimmune disease; | ABBOTT LABORATORIES | 2004-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167188-A1 | Controlling gene expression; antidiabetic agents; insulin resistance; autoimmune disease; | G6PC1, PPP1R1B, PPP1R7 | PARP1 4490/4885ALDH1A1 758/4885GLA 2323/4885 |
| US-20040214870-A1 | Controlling gene expression; antidiabetic agents; insulin resistance; autoimmune disease; 5-(3-((1E)-3-(3-hydroxy-2-(methoxycarbonyl)phenoxy)prop-1-enyl)phenyl)isoxazole-3-carboxylic acid | G6PC1, PPP1R7, PPP1R1B | PARP1 4442/4885ALDH1A1 710/4885GLA 2825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.