Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554785 | 0.76 | DRD3 (0.54) | SMN1; SMN2SLC6A4SLC6A3HDAC4 | |
| SCHEMBL26413489 | 0.74 | PTGDR2 (0.43) | MAPTMEN1KMT2A | |
| SCHEMBL290859 | 0.71 | CYP19A1 (0.40) | ALDH1A1SMN1; SMN2MAPTCYP19A1TSHR | |
| SCHEMBL6036780 | 0.70 | HDAC4 (0.47) | ALDH1A1SLC6A2SLC6A4SLC6A3HDAC4 | |
| SCHEMBL4903380 | 0.69 | HSD11B1 (0.41) | ALDH1A1SMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24397743 | 0.69 | DRD2 (0.39) | ALDH1A1SMN1; SMN2MAPTHDAC4LMNA | |
| SCHEMBL5844286 | 0.68 | CYP4F2 (0.61) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL24821237 | 0.68 | KMT2A (0.77) | POLBALDH1A1LMNATHRBMEN1 | |
| SCHEMBL296162 | 0.67 | TAAR1 (0.60) | POLBALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL2867587 | 0.67 | ALDH1A1 (0.69) | POLBALDH1A1SMN1; SMN2TSHRHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757669-A1 | O-ACYL-4-PHENYL-CYCLOHEXANOLS, THEIR SALTS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE, AS WELL AS A METHOD OF PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-02-12 | — | — | EP | claimed |
| WO-1995029148-A1 | O-ACYL-4-PHENYL-CYCLOHEXANOLS, THEIR SALTS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE, AS WELL AS A METHOD OF PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1995-11-02 | — | — | WO | claimed |