Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | AGER | Q15109 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2935558 | 0.96 | KDM4E (0.36) | KDM4EASPHKDM8IGFBP3ALDH1A1 | |
| Zinc Ion SCHEMBL28574219 | 0.74 | KDM4E (0.39) | KDM4EASPHKDM8ALDH1A1CA1 | |
| Zinc Ion SCHEMBL28582478 | 0.74 | KDM4E (0.35) | KDM4EASPHKDM8ALDH1A1CA1 | |
| SCHEMBL29843137 | 0.73 | KDM4E (0.34) | KDM4EASPHKDM8ALDH1A1CA2 | |
| SCHEMBL8645022 | 0.72 | KDM4E (0.33) | KDM4EASPHKDM8CA1CA2 | |
| SCHEMBL1002512 | 0.71 | KDM4E (0.52) | KDM4EASPHKDM8IGFBP3ALDH1A1 | |
| Zinc Ion SCHEMBL28914309 | 0.71 | KDM4E (0.33) | KDM4EASPHKDM8 | |
| Zinc Ion SCHEMBL28573124 | 0.71 | LMNA (0.39) | KDM4EASPHKDM8ALDH1A1CA1 | |
| Zinc Ion SCHEMBL28572535 | 0.71 | L3MBTL1 (0.41) | KDM4EALDH1A1CA1CA2CA12 | |
| Zinc Ion SCHEMBL28573603 | 0.71 | KDM4E (0.33) | KDM4EASPHKDM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5626839-A | Light responsive self-tanning products and methods for use | SCALES-MEDEIROS VIRGINIA (US) | 1997-05-06 | — | — | US | disclosed |