Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119211 | 0.76 | RARB (0.47) | ALDH1A1LMNA | |
| SCHEMBL7838471 | 0.74 | RXRA (0.49) | ALDH1A1LMNA | |
| SCHEMBL7849442 | 0.72 | RXRA (0.43) | PDE7APDE7B | |
| SCHEMBL7839571 | 0.71 | SMN1; SMN2 (0.43) | SRD5A2ALDH1A1LMNA | |
| SCHEMBL8780435 | 0.70 | TSHR (0.45) | NR1H4PDE7APDE7BSRD5A2TSHR | |
| SCHEMBL8780448 | 0.68 | PDE7A (0.45) | PDE7APDE7BALDH1A1LMNADHFR | |
| SCHEMBL12126296 | 0.67 | PTPN1 (0.55) | TSHRALDH1A1 | |
| SCHEMBL4058443 | 0.66 | ADAM17 (0.54) | PDE7APDE7BSRD5A2TSHRALDH1A1 | |
| SCHEMBL30977564 | 0.65 | LTB4R (0.43) | ALDH1A1LMNAAPOBEC3AAPOBEC3G | |
| SCHEMBL1682210 | 0.65 | LTB4R (0.43) | ALDH1A1LMNAAPOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498722-B1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-07-30 | — | — | EP | disclosed |
| EP-0498722-A1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1992-08-12 | — | — | EP | disclosed |