SCHEMBL8780573

SCHEMBL8780573

Cc1c(F)c(F)cc(Oc2cccnc2C(=O)Nc2ccc(F)cc2F)c1F

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
P2RY1 P47900 6/20 0.48
CYP1A2 P05177 2/20 0.45
CYP2C19 P33261 2/20 0.45
KDM4E B2RXH2 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
RAB9A P51151 1/20 0.45
ALDH1A1 P00352 1/20 0.44
CACNA1B Q00975 1/20 0.44
APBA1 Q02410 1/20 0.44
MAPT P10636 2/20 0.44
PPIA P62937 1/20 0.44
TP53 P04637 1/20 0.44
POLB P06746 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
GPR6 P46095 1/20 0.44
MET P08581 2/20 0.43
CYP3A4 P08684 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6452431 0.86 KMT2A (0.61) P2RY1CYP1A2CYP2C19KDM4EMEN1
SCHEMBL8780580 0.80 CYP1A2 (0.50) P2RY1CYP1A2CYP2C19KDM4EKMT2A
SCHEMBL8780571 0.80 KDR (0.47) RAB9AGPR6MET
SCHEMBL8780572 0.80 MET (0.47) CYP1A2CYP2C19KDM4ERAB9AALDH1A1
SCHEMBL8780581 0.79 RAB9A (0.47) CYP1A2CYP2C19KDM4EMEN1KMT2A
SCHEMBL8780568 0.78 NPC1 (0.53) CYP1A2CYP2C19KDM4EKMT2ARAB9A
SCHEMBL8780574 0.76 NPC1 (0.49) CYP1A2CYP2C19KDM4EKMT2ARAB9A
SCHEMBL7645488 0.75 KDM4E (0.74) P2RY1CYP1A2CYP2C19KDM4EMEN1
SCHEMBL11247737 0.73 KMT2A (0.64) CYP1A2CYP2C19KDM4EMEN1KMT2A
SCHEMBL11234692 0.73 KMT2A (0.47) CYP1A2CYP2C19KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0806414-A1 Intermediates for herbicidal carboxamide derivatives SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1997-11-12 EP disclosed