SCHEMBL8780581

SCHEMBL8780581

Cc1c(F)c(F)cc(Oc2ccc(C(=O)Nc3ccc(F)cc3F)nc2)c1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.47
NPC1 O15118 4/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
GAA P10253 1/20 0.47
KDM4E B2RXH2 2/20 0.46
ALDH1A1 P00352 2/20 0.46
CYP1A2 P05177 2/20 0.46
CYP3A4 P08684 2/20 0.46
CYP2C19 P33261 2/20 0.46
CYP2C9 P11712 1/20 0.46
S1PR3 Q99500 1/20 0.45
HSD17B10 Q99714 2/20 0.44
RXFP1 Q9HBX9 1/20 0.44
KMT2A Q03164 2/20 0.44
MEN1 O00255 1/20 0.44
HPGD P15428 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
LMNA P02545 1/20 0.44
GPR6 P46095 1/20 0.44
KDR P35968 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8780571 0.86 KDR (0.47) RAB9ANPC1SMN1; SMN2GAAS1PR3
SCHEMBL8780574 0.82 NPC1 (0.49) RAB9ANPC1SMN1; SMN2GAAKDM4E
SCHEMBL8780568 0.80 NPC1 (0.53) RAB9ANPC1SMN1; SMN2GAAKDM4E
SCHEMBL8780573 0.79 P2RY1 (0.48) RAB9AKDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL8780572 0.78 MET (0.47) RAB9ANPC1SMN1; SMN2GAAKDM4E
SCHEMBL8780580 0.78 CYP1A2 (0.50) RAB9ANPC1SMN1; SMN2GAAKDM4E
SCHEMBL6452431 0.78 KMT2A (0.61) KDM4ECYP1A2CYP2C19KMT2AMEN1
SCHEMBL7612484 0.74 NPSR1 (0.66) GAAKDM4ECYP1A2CYP3A4CYP2C19
SCHEMBL4763131 0.69 HTT (0.62) RAB9ANPC1SMN1; SMN2GAAKDM4E
SCHEMBL30772495 0.68 RAB9A (0.42) RAB9ANPC1KDM4EKMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0806414-A1 Intermediates for herbicidal carboxamide derivatives SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1997-11-12 EP disclosed