Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780790 | 0.84 | BCHE (0.42) | HTR1ASIGMAR1KCNH2LMNAKMT2A | |
| SCHEMBL8780889 | 0.82 | SLC22A2 (0.40) | SIGMAR1DRD2CYP3A4KCNH2KDM4E | |
| SCHEMBL8780974 | 0.81 | DRD2 (0.42) | SIGMAR1DRD2CYP3A4KDM4ECYP2D6 | |
| SCHEMBL8780859 | 0.81 | SLC22A2 (0.42) | KCNH2GPR84SLC22A2ADRB1SLC6A4 | |
| SCHEMBL8780897 | 0.78 | SLC22A2 (0.46) | KCNH2KDM4EMAPK1RAB9AHSD17B10 | |
| SCHEMBL8780752 | 0.77 | MAPT (0.45) | HTR1ASIGMAR1DRD2CYP3A4KCNH2 | |
| SCHEMBL8780776 | 0.77 | MAOA (0.37) | HTR1ACYP3A4KCNH2LMNACHRM2 | |
| SCHEMBL8780893 | 0.74 | KCNH2 (0.59) | HTR1AKCNH2KDM4ELMNACHRM2 | |
| SCHEMBL8781005 | 0.74 | KCNH2 (0.57) | SIGMAR1CYP3A4KCNH2SMN1; SMN2SLC22A2 | |
| SCHEMBL8780744 | 0.74 | SLC22A2 (0.48) | SIGMAR1DRD2KCNH2LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |