Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.53 |
| ▸ | HTR1A | P08908 | 10/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | HTR1D | P28221 | 7/20 | 0.53 |
| ▸ | HTR1B | P28222 | 7/20 | 0.53 |
| ▸ | DRD4 | P21917 | 9/20 | 0.53 |
| ▸ | DRD3 | P35462 | 9/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594420 | 0.84 | DRD4 (0.74) | DRD2HTR1AHTR2AHTR1DHTR1B | |
| SCHEMBL8786686 | 0.83 | DRD2 (0.60) | DRD2HTR1AHTR2AHTR1DHTR1B | |
| SCHEMBL8195715 | 0.82 | PARP1 (0.60) | DRD2HTR1AHTR2AHTR1DHTR1B | |
| SCHEMBL8785358 | 0.81 | HTR1A (0.73) | DRD2HTR1AHTR2AHTR1DHTR1B | |
| SCHEMBL14510673 | 0.80 | HTR1A (0.62) | DRD2HTR1AHTR2AHTR1DHTR1B | |
| SCHEMBL9595103 | 0.78 | HTR1A (0.71) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL9449665 | 0.78 | MAOB (0.48) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL21207261 | 0.77 | PARP1 (0.74) | DRD2HTR1AHTR1DHTR1BDRD4 | |
| SCHEMBL12346687 | 0.77 | HTR1A (0.58) | DRD2HTR1AHTR2AHTR1DHTR1B | |
| SCHEMBL2056366 | 0.77 | PARP1 (0.77) | DRD2HTR1AHTR2ADRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0478446-B1 | Heterocyclic alkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-11-19 | — | — | EP | claimed |
| EP-0478446-A1 | Heterocyclic alkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-04-01 | — | — | EP | claimed |