Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 13/20 | 0.41 |
| ▸ | CA1 | P00915 | 11/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 11/20 | 0.39 |
| ▸ | CA12 | O43570 | 8/20 | 0.39 |
| ▸ | CA4 | P22748 | 4/20 | 0.39 |
| ▸ | CA6 | P23280 | 4/20 | 0.39 |
| ▸ | CA5A | P35218 | 4/20 | 0.39 |
| ▸ | CA7 | P43166 | 4/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21233203 | 0.82 | TRPM5 (0.42) | LMNARAB9A | |
| SCHEMBL30952445 | 0.82 | TRPM5 (0.39) | PKMTDP1KMT2AMEN1 | |
| SCHEMBL693306 | 0.82 | TRPM5 (0.39) | PKMTDP1KMT2AMEN1 | |
| SCHEMBL4659346 | 0.82 | ALDH1A1 (0.41) | LMNACA2CA1CA12CA7 | |
| Hydrochloric Acid SCHEMBL27845581 | 0.81 | ALDH1A1 (0.40) | LMNATDP1KMT2AKDM4EMEN1 | |
| SCHEMBL22951427 | 0.78 | ALDH1A1 (0.41) | LMNAPKMKMT2AKDM4EMEN1 | |
| Sulfanilamide SCHEMBL1499915 | 0.76 | CA2 (0.52) | LMNACA2CA1CA9CA12 | |
| SCHEMBL31235124 | 0.72 | ALOX5AP (0.48) | — | |
| SCHEMBL9839080 | 0.71 | LMNA (0.82) | LMNACA2CA1PKMCA9 | |
| SCHEMBL1354208 | 0.71 | FLT3 (0.41) | LMNACA2PKMTDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757674-A1 | SUBSTITUTED SULFONAMIDES AS SELECTIVE $g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY | Merck & Co., Inc. (US) | 1997-02-12 | — | — | EP | claimed |
| WO-1995029159-A1 | SUBSTITUTED SULFONAMIDES AS SELECTIVE β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY | MERCK & CO., INC. (US) | 1995-11-02 | — | — | WO | claimed |