Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PPIB | P23284 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789786 | 0.87 | CDK8 (0.56) | LTB4RLTB4R2AOC3RAB9AALDH1A1 | |
| SCHEMBL8790187 | 0.86 | LTB4R (0.59) | LTB4RLTB4R2AOC3ALOX5PPIB | |
| SCHEMBL8789904 | 0.86 | MAPK1 (0.75) | MAPK1NPSR1PPIBSMN1; SMN2NPC1 | |
| SCHEMBL8790474 | 0.84 | ALOX5 (0.66) | LTB4RLTB4R2AOC3ALOX5PPIB | |
| SCHEMBL8790726 | 0.83 | ALDH1A1 (0.63) | MAPK1SMN1; SMN2KCNH2RAB9AALDH1A1 | |
| SCHEMBL16438642 | 0.79 | MAPK1 (0.62) | MAPK1HIF1ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL9023046 | 0.77 | ALOX5 (0.55) | LTB4RLTB4R2AOC3ALOX5SMN1; SMN2 | |
| SCHEMBL8789557 | 0.77 | AOC3 (0.66) | MAPK1AOC3KCNH2ALDH1A1 | |
| SCHEMBL8788832 | 0.76 | MAPK1 (0.56) | MAPK1NPSR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8790580 | 0.76 | ALDH1A1 (0.61) | MAPK1ALOX5PPIBSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |