Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9568794 | 0.86 | ALDH1A1 (0.51) | HSD11B1PTGS2ALDH1A1MGLLCYP1A2 | |
| SCHEMBL8791363 | 0.84 | NQO2 (0.42) | HSD11B1PTGS2ALDH1A1TSHRMGLL | |
| SCHEMBL9469455 | 0.82 | OGT (0.41) | HSD11B1ALDH1A1TSHRMGLLHTT | |
| SCHEMBL9568762 | 0.81 | POLB (0.51) | PTGS2ALDH1A1HTTPOLBCYP1A2 | |
| SCHEMBL7114830 | 0.80 | BRD4 (0.40) | PTGS2MGLLHSD17B10KMT2AALOX15 | |
| SCHEMBL9568852 | 0.79 | HSD11B1 (0.50) | HSD11B1PTGS2ALDH1A1HSD17B10 | |
| SCHEMBL7107743 | 0.79 | ALDH1A1 (0.50) | PTGS2ALDH1A1TSHRHTTPOLB | |
| SCHEMBL9542013 | 0.78 | TSHR (0.46) | HSD11B1ALDH1A1TSHRHTTPOLB | |
| SCHEMBL8790766 | 0.77 | KMT2A (0.48) | ALDH1A1TSHRHDAC6CYP1A2HSD17B10 | |
| SCHEMBL8791403 | 0.77 | ALDH1A1 (0.49) | ALDH1A1TSHRHTTCYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262433-A | Antidiabetic agents | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1993-11-16 | — | — | US | disclosed |
| EP-0528277-A1 | Tetrazoleacetic acid derivatives aldose reductase inhibitors | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1993-02-24 | — | — | EP | disclosed |