Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846745 | 0.94 | ROCK2 (0.47) | ROCK2ADORA2AADORA1L3MBTL1MEN1 | |
| SCHEMBL846130 | 0.86 | L3MBTL1 (0.44) | ADORA2AADORA1L3MBTL1MEN1MAPT | |
| SCHEMBL846336 | 0.84 | ADORA2A (0.43) | ADORA2AADORA1L3MBTL1MEN1MAPT | |
| SCHEMBL1257088 | 0.82 | ALDH1A1 (0.44) | ADORA2AADORA1L3MBTL1MEN1MAPT | |
| SCHEMBL846068 | 0.82 | KDM4E (0.42) | ADORA2AADORA1L3MBTL1MEN1MAPT | |
| SCHEMBL846258 | 0.82 | L3MBTL1 (0.40) | ADORA2AADORA1L3MBTL1MEN1MAPT | |
| SCHEMBL1255710 | 0.82 | L3MBTL1 (0.46) | ADORA2AADORA1L3MBTL1MEN1MAPT | |
| SCHEMBL1254725 | 0.82 | L3MBTL1 (0.45) | ADORA2AADORA1L3MBTL1MEN1MAPT | |
| SCHEMBL1254213 | 0.81 | ADORA2A (0.52) | ROCK2ADORA2AADORA1 | |
| SCHEMBL879472 | 0.81 | ADORA2A (0.40) | ADORA2AADORA1L3MBTL1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433938-A1 | THERAPEUTIC AGENT FOR MOTOR DISORDERS | Kyowa Hakko Kirin Co., Ltd. (JP) | 2012-03-28 | — | — | EP | disclosed |