Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 10/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19330952 | 0.85 | MEN1 (0.48) | MAPTPOLBCDK1CDK2MET | |
| SCHEMBL8794456 | 0.85 | MTNR1A (0.47) | MAPTPOLBCA12CA1CA2 | |
| SCHEMBL6594503 | 0.82 | MAPT (0.47) | MAPTPOLBMETMEN1KMT2A | |
| SCHEMBL19331259 | 0.75 | KDM4E (0.46) | MAPTPOLBCDK1CDK2MET | |
| SCHEMBL8586323 | 0.75 | TUBB1 (0.44) | MAPTMETMEN1KMT2AKDM4E | |
| SCHEMBL3830749 | 0.74 | MAPT (0.46) | MAPTPOLBCA12CA1CA2 | |
| Acetic Acid SCHEMBL27315086 | 0.73 | TUBB1 (0.42) | MAPTMETMEN1KMT2AKDM4E | |
| SCHEMBL17417733 | 0.72 | PRKAG1 (0.51) | MAPTKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL8564952 | 0.71 | ALDH1A1 (0.61) | MAPTCA12CA1CA2CA7 | |
| SCHEMBL8794342 | 0.71 | MTNR1A (0.46) | MAPTPOLBMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652239-A | TREATMENT OF STROKES, ISCHEMIC ATTACK, ANTAGONISTS OF EXCITATORY AMINO ACIDS GLUTAMATE AND ASPARTATE | IMPERIAL CHEMICAL COMPANY (GB) | 1997-07-29 | — | — | US | disclosed |
| EP-0512817-B1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| EP-0512817-A1 | Pyridazinedione derivatives, their preparation and pharmaceutical applications | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |