SCHEMBL879547

SCHEMBL879547

CNC(=O)N(O)c1ccccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ POLB P06746 3/20 0.37
▸ SLC6A2 P23975 1/20 0.37
▸ SLC6A4 P31645 1/20 0.37
▸ KMT2A Q03164 3/20 0.37
▸ SMN1; SMN2 Q16637 3/20 0.37
▸ HSD17B10 Q99714 2/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ ALOX15 P16050 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ CES2 O00748 1/20 0.36
▸ CES1 P23141 1/20 0.36
▸ GAA P10253 2/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ GLA P06280 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ GPBAR1 Q8TDU6 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11815635 0.84 MAPT (0.41) ALDH1A1POLBKMT2ASMN1; SMN2MEN1
SCHEMBL2736489 0.81 ALDH1A1 (0.43) ALDH1A1POLBSLC6A2SLC6A4KMT2A
SCHEMBL11542282 0.80 ALDH1A1 (0.38) ALDH1A1L3MBTL1POLBSLC6A2SLC6A4
SCHEMBL11445933 0.79 APEX1 (0.36) ALDH1A1KMT2ASMN1; SMN2MAPTRAB9A
SCHEMBL11811760 0.79 ALDH1A1 (0.42) ALDH1A1L3MBTL1POLBKMT2ASMN1; SMN2
SCHEMBL10835825 0.79 POLB (0.41) ALDH1A1POLBKMT2ASMN1; SMN2HSD17B10
SCHEMBL879555 0.78 HPGD (0.44) ALDH1A1L3MBTL1POLBSLC6A2SLC6A4
SCHEMBL25774606 0.78 BCL2A1 (0.40) ALDH1A1L3MBTL1POLBKMT2ASMN1; SMN2
SCHEMBL27481296 0.78 GAA (0.47) ALDH1A1L3MBTL1KMT2ASMN1; SMN2MEN1
SCHEMBL11036446 0.72 SMN1; SMN2 (0.49) ALDH1A1L3MBTL1KMT2ASMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9677053-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2017-06-13 — — US disclosed
US-9677053-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2017-06-13 — — US disclosed
US-20160237411-A1 LACCASES FOR BIO-BLEACHING VERENIUM CORPORATION 2016-08-18 — — US disclosed
US-20160237411-A1 LACCASES FOR BIO-BLEACHING VERENIUM CORPORATION 2016-08-18 — — US disclosed
US-9353477-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2016-05-31 — — US disclosed
US-9353477-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2016-05-31 — — US disclosed
EP-2434008-B1 Laccases for pulp bio-bleaching BASF ENZYMES LLC (US) 2015-07-08 — — EP disclosed
US-20150125936-A1 LACCASES FOR BIO-BLEACHING BASF SE (DE) 2015-05-07 — — US disclosed
US-20150125936-A1 LACCASES FOR BIO-BLEACHING BASF SE (DE) 2015-05-07 — — US disclosed
US-8951766-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2015-02-10 — — US disclosed
US-8951766-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2015-02-10 — — US disclosed
US-20130126110-A1 LACCASES FOR BIO-BLEACHING BASF SE (DE) 2013-05-23 — — US disclosed
US-20130126110-A1 LACCASES FOR BIO-BLEACHING BASF SE (DE) 2013-05-23 — — US disclosed
US-8377670-B2 Laccases for bio-bleaching VERENIUM CORPORATION (US) 2013-02-19 — — US disclosed
US-8377670-B2 Laccases for bio-bleaching VERENIUM CORPORATION (US) 2013-02-19 — — US disclosed
EP-2434008-A1 Laccases for pulp bio-bleaching Verenium Corporation (US) 2012-03-28 — — EP disclosed
EP-2059587-B1 LACCASES FOR PULP BIO-BLEACHING VERENIUM CORP (US) 2012-01-04 — — EP disclosed
US-20100018658-A1 Laccases for Bio-Bleaching VERENIUM CORPORATION (US) 2010-01-28 — — US disclosed
US-20100018658-A1 Laccases for Bio-Bleaching VERENIUM CORPORATION (US) 2010-01-28 — — US disclosed
WO-2008027501-A2 LACCASES FOR PULP BIO-BLEACHING VERENIUM CORPORATION (US) 2008-03-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100018658-A1 Laccases for Bio-Bleaching AOX1, GUSB, LPO ALDH1A1 238/4885L3MBTL1 787/4885POLB 62/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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