SCHEMBL879555

SCHEMBL879555

CCCNC(=O)N(O)c1ccccc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 1/20 0.44
▸ POLB P06746 1/20 0.41
▸ THRB P10828 1/20 0.41
▸ RECQL P46063 1/20 0.41
▸ TDP1 Q9NUW8 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ KMT2A Q03164 2/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ RAB9A P51151 3/20 0.40
▸ HTT P42858 2/20 0.39
▸ ESR1 P03372 1/20 0.39
▸ PTGES O14684 1/20 0.39
▸ CHRM2 P08172 1/20 0.38
▸ CYP2D6 P10635 1/20 0.38
▸ CHRM1 P11229 1/20 0.38
▸ ADRA2C P18825 1/20 0.38
▸ CHRM3 P20309 1/20 0.38
▸ SLC6A2 P23975 1/20 0.38
▸ SLC6A4 P31645 1/20 0.38
▸ OPRM1 P35372 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2736489 0.87 ALDH1A1 (0.43) HPGDPOLBKMT2AHSD17B10RAB9A
SCHEMBL14963062 0.83 RAB9A (0.44) HPGDPOLBKMT2ARAB9APTGES
SCHEMBL16882672 0.81 HTT (0.38) HPGDPOLBTHRBRECQLTDP1
SCHEMBL13543371 0.81 RAB9A (0.47) HPGDPOLBTHRBRECQLTDP1
SCHEMBL879548 0.81 HPGD (0.41) HPGDPOLBTHRBRECQLTDP1
SCHEMBL10067518 0.79 NPC1 (0.44) L3MBTL1HSD17B10RAB9AESR1ALDH1A1
SCHEMBL879547 0.78 ALDH1A1 (0.39) HPGDPOLBRECQLL3MBTL1KMT2A
SCHEMBL2736838 0.76 MAPT (0.48) POLBKMT2AHSD17B10HTTCYP2D6
SCHEMBL11784631 0.74 HPGD (0.54) HPGDPOLBRAB9AHTTALDH1A1
SCHEMBL10835825 0.72 POLB (0.41) HPGDPOLBKMT2AHSD17B10ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9677053-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2017-06-13 — — US disclosed
US-9677053-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2017-06-13 — — US disclosed
US-20160237411-A1 LACCASES FOR BIO-BLEACHING VERENIUM CORPORATION 2016-08-18 — — US disclosed
US-20160237411-A1 LACCASES FOR BIO-BLEACHING VERENIUM CORPORATION 2016-08-18 — — US disclosed
US-9353477-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2016-05-31 — — US disclosed
US-9353477-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2016-05-31 — — US disclosed
EP-2434008-B1 Laccases for pulp bio-bleaching BASF ENZYMES LLC (US) 2015-07-08 — — EP disclosed
US-20150125936-A1 LACCASES FOR BIO-BLEACHING BASF SE (DE) 2015-05-07 — — US disclosed
US-20150125936-A1 LACCASES FOR BIO-BLEACHING BASF SE (DE) 2015-05-07 — — US disclosed
US-8951766-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2015-02-10 — — US disclosed
US-8951766-B2 Laccases for bio-bleaching BASF ENZYMES LLC (US) 2015-02-10 — — US disclosed
US-20130126110-A1 LACCASES FOR BIO-BLEACHING BASF SE (DE) 2013-05-23 — — US disclosed
US-20130126110-A1 LACCASES FOR BIO-BLEACHING BASF SE (DE) 2013-05-23 — — US disclosed
US-8377670-B2 Laccases for bio-bleaching VERENIUM CORPORATION (US) 2013-02-19 — — US disclosed
US-8377670-B2 Laccases for bio-bleaching VERENIUM CORPORATION (US) 2013-02-19 — — US disclosed
EP-2434008-A1 Laccases for pulp bio-bleaching Verenium Corporation (US) 2012-03-28 — — EP disclosed
EP-2059587-B1 LACCASES FOR PULP BIO-BLEACHING VERENIUM CORP (US) 2012-01-04 — — EP disclosed
US-20100018658-A1 Laccases for Bio-Bleaching VERENIUM CORPORATION (US) 2010-01-28 — — US disclosed
US-20100018658-A1 Laccases for Bio-Bleaching VERENIUM CORPORATION (US) 2010-01-28 — — US disclosed
WO-2008027501-A2 LACCASES FOR PULP BIO-BLEACHING VERENIUM CORPORATION (US) 2008-03-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100018658-A1 Laccases for Bio-Bleaching AOX1, GUSB, LPO HPGD 2088/4885POLB 62/4885THRB 2580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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