Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 2/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 4/20 | 0.43 |
| ▸ | MDH1 | P40925 | 3/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | MDH2 | P40926 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797137 | 1.00 | PLA2G4A (0.48) | PLA2G4APLA2G4BMDH1SMPD1NFKB1 | |
| SCHEMBL8796548 | 0.88 | SMPD1 (0.37) | PLA2G4AMDH1SMPD1POLBMAPT | |
| SCHEMBL8796557 | 0.88 | SMPD1 (0.37) | PLA2G4AMDH1SMPD1POLBMAPT | |
| SCHEMBL8795838 | 0.87 | PLA2G4A (0.46) | PLA2G4APLA2G4BSMPD1NFKB1NFKB2 | |
| SCHEMBL8795848 | 0.87 | PLA2G4A (0.46) | PLA2G4APLA2G4BSMPD1NFKB1NFKB2 | |
| SCHEMBL8795820 | 0.81 | NPC1 (0.39) | PLA2G4ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL8795809 | 0.81 | NPC1 (0.39) | PLA2G4ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL8796565 | 0.76 | PTPN11 (0.37) | PLA2G4ASMPD1SMN1; SMN2 | |
| SCHEMBL8795222 | 0.76 | KMT2A (0.44) | NPC1POLBMAPTSMN1; SMN2LMNA | |
| SCHEMBL8795499 | 0.76 | KMT2A (0.44) | NPC1POLBMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |