Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 5/20 | 0.32 |
| ▸ | GSK3B | P49841 | 5/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.32 |
| ▸ | CDK1 | P06493 | 3/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.31 |
| ▸ | MAP2 | P11137 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057850 | 0.78 | MYC (0.36) | MYCIKBKBTTR | |
| SCHEMBL8797191 | 0.70 | RAB9A (0.47) | ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8910392 | 0.69 | CCNB2 (0.32) | GSK3AGSK3BCDK5CDK5R1CCNB2 | |
| SCHEMBL8142537 | 0.69 | MYC (0.34) | MYCKMT2AGSK3AGSK3BCDK5 | |
| SCHEMBL8797844 | 0.69 | NPC1 (0.36) | MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8536552 | 0.69 | GAA (0.32) | ALDH1A1LMNAHSP90AA1MAPTHTT | |
| SCHEMBL8149445 | 0.65 | TERT (0.36) | MEN1KMT2ASMN1; SMN2BRD4 | |
| SCHEMBL8910714 | 0.64 | ALDH1A1 (0.34) | MEN1KMT2AALDH1A1LMNAHSP90AA1 | |
| SCHEMBL8909578 | 0.64 | HPGD (0.41) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL191346 | 0.62 | IDO1 (0.40) | MEN1KMT2AALDH1A1LMNAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769012-A1 | TETRACYCLIC DERIVATIVES AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-04-23 | — | — | EP | disclosed |
| WO-1996001827-A1 | TETRACYCLIC DERIVATIVES AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-01-25 | — | — | WO | disclosed |