Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 10/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.41 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796811 | 0.84 | SLC40A1 (0.40) | ABCC9ABCC8KCNJ11KCNJ8HTR6 | |
| SCHEMBL9097096 | 0.80 | POLB (0.50) | ABCC9ABCC8KCNJ11KCNJ8RAB9A | |
| SCHEMBL15652223 | 0.79 | ALDH1A1 (0.39) | ABCC9ABCC8KCNJ11KCNJ8NPC1 | |
| SCHEMBL16698974 | 0.78 | AKR1C3 (0.46) | ABCC9ABCC8KCNJ11KCNJ8NPC1 | |
| SCHEMBL8017713 | 0.77 | KMT2A (0.62) | — | |
| SCHEMBL775608 | 0.75 | HTR2C (0.59) | NFE2L2HTR2AABCC9ABCC8KCNJ11 | |
| SCHEMBL1094871 | 0.75 | ALDH1A1 (0.57) | SMN1; SMN2 | |
| SCHEMBL502516 | 0.73 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8SMN1; SMN2 | |
| SCHEMBL9460224 | 0.73 | HTR2C (0.50) | NFE2L2HTR2AABCC9ABCC8KCNJ11 | |
| SCHEMBL27470883 | 0.71 | NFE2L2 (0.60) | NFE2L2HTR2AHTR2CHTR2BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |