Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 5/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799338 | 0.76 | ALOX5 (0.52) | ALOX5PARP10PARP15CACNA1BMMP13 | |
| SCHEMBL8800932 | 0.71 | ALOX5 (0.46) | ALOX5CACNA1BMMP13MMP14 | |
| SCHEMBL8799902 | 0.70 | ALOX5 (0.53) | ALOX5CACNA1BMMP13MMP14 | |
| SCHEMBL17760501 | 0.69 | SCN9A (0.37) | ALOX5P2RX1SCN9A | |
| SCHEMBL3590769 | 0.69 | MAOB (0.46) | ALOX5METPARP10PKMPARP15 | |
| SCHEMBL28168093 | 0.68 | SLC6A3 (0.36) | ALOX5P2RX1SCN9A | |
| Lithium Ion SCHEMBL3590770 | 0.68 | MAOB (0.42) | ALOX5METPARP10PKMPARP15 | |
| SCHEMBL20305349 | 0.67 | ALOX5 (0.39) | ALOX5METMAOBMAOAMMP13 | |
| SCHEMBL8801528 | 0.67 | ALOX5 (0.51) | ALOX5CACNA1B | |
| SCHEMBL3583451 | 0.67 | MAOB (0.44) | ALOX5METPARP10PKMMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5512581-A | ANTIINFLAMMATORY AGENT | ABBOTT LABORATORIES (US) | 1996-04-30 | — | — | US | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |