Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800932 | 0.78 | ALOX5 (0.46) | ALOX5MMP13MMP14HPGDCACNA1B | |
| SCHEMBL16621263 | 0.77 | NR4A2 (0.53) | ALOX5POLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8799902 | 0.77 | ALOX5 (0.53) | ALOX5MMP13MMP14CACNA1B | |
| SCHEMBL6902866 | 0.77 | EGFR (0.58) | PARP10RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL5510308 | 0.77 | EGFR (0.58) | PARP10RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL8799334 | 0.76 | ALOX5 (0.46) | ALOX5PARP15PARP10MMP13MMP14 | |
| SCHEMBL8801528 | 0.73 | ALOX5 (0.51) | ALOX5CACNA1B | |
| SCHEMBL8965350 | 0.73 | ALOX5 (0.53) | ALOX5 | |
| SCHEMBL8800909 | 0.72 | ALOX5 (0.58) | ALOX5 | |
| SCHEMBL8965181 | 0.72 | ALOX5 (0.51) | ALOX5MMP13MMP14CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5512581-A | ANTIINFLAMMATORY AGENT | ABBOTT LABORATORIES (US) | 1996-04-30 | — | — | US | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |