Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799338 | 0.78 | ALOX5 (0.52) | ALOX5MMP13MMP14HPGDCACNA1B | |
| SCHEMBL8799902 | 0.77 | ALOX5 (0.53) | ALOX5LTA4HHRH3MMP13MMP14 | |
| SCHEMBL8800909 | 0.72 | ALOX5 (0.58) | ALOX5 | |
| SCHEMBL8799334 | 0.71 | ALOX5 (0.46) | ALOX5MMP13MMP14CACNA1B | |
| SCHEMBL8968723 | 0.70 | ALOX5 (0.54) | ALOX5LTA4HMMP13MMP14 | |
| SCHEMBL4088281 | 0.70 | SLC6A3 (0.47) | ALOX5LTA4H | |
| SCHEMBL17760501 | 0.69 | SCN9A (0.37) | ALOX5LTA4HHRH3 | |
| SCHEMBL18038881 | 0.69 | KDM4C (0.42) | ALOX5LTA4HHPGD | |
| SCHEMBL1928819 | 0.68 | ALOX5 (0.47) | ALOX5LTA4H | |
| SCHEMBL386638 | 0.67 | MAOB (0.55) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |