Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798493 | 0.87 | USP2 (0.52) | NPC1HTTRAB9AKMT2AMEN1 | |
| SCHEMBL8797556 | 0.84 | CYP11B2 (0.58) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL7568546 | 0.77 | CHRNB2 (0.62) | HTTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL8798613 | 0.76 | DHODH (0.54) | RAB9AKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL12424811 | 0.76 | CYP11B2 (0.49) | NPC1HTTRAB9AALDH1A1KMT2A | |
| SCHEMBL7493834 | 0.76 | KMT2A (0.65) | NPC1HTTRAB9ATYK2ALDH1A1 | |
| SCHEMBL8801750 | 0.75 | USP2 (0.47) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL8798058 | 0.75 | ALDH1A1 (0.55) | NPC1HTTRAB9AALDH1A1KMT2A | |
| SCHEMBL8613320 | 0.75 | DHODH (0.52) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL13968402 | 0.74 | KMT2A (0.46) | NPC1HTTRAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811008-A1 | BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-12-10 | — | — | EP | disclosed |