Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.62 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.62 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959588 | 0.80 | KMT2A (0.61) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL7493834 | 0.80 | KMT2A (0.65) | KMT2AL3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL10635334 | 0.79 | CHRNB2 (0.56) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL7501376 | 0.77 | KMT2A (0.63) | KMT2AL3MBTL1GAAMAPTMEN1 | |
| SCHEMBL8799679 | 0.77 | NPC1 (0.57) | KMT2AL3MBTL1ALDH1A1HTTLMNA | |
| SCHEMBL6778676 | 0.77 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL29077108 | 0.75 | NPC1 (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL229441 | 0.75 | BCAT2 (0.63) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL7570263 | 0.74 | KCNK3 (0.50) | KMT2AL3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL7570572 | 0.73 | NAMPT (0.55) | KMT2AL3MBTL1ALDH1A1HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915876-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1999-05-19 | — | — | EP | disclosed |
| US-5719278-A | TREATING EXCESS RENAL REABSORPTION OF WATER | AMERICAN CYANAMID COMPANY (US) | 1998-02-17 | — | — | US | disclosed |
| WO-1997049707-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-31 | — | — | WO | disclosed |