Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 3/20 | 0.39 |
| ▸ | TOP2A | P11388 | 2/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803902 | 0.93 | ALDH1A1 (0.52) | PIM1ALDH1A1KDM4EPOLBHSP90AA1 | |
| SCHEMBL8801570 | 0.89 | PIM1 (0.37) | PIM1ALDH1A1KDM4EPOLBHSP90AA1 | |
| SCHEMBL8802764 | 0.86 | CYP3A4 (0.45) | PIM1ALDH1A1KDM4EPOLBHSP90AA1 | |
| SCHEMBL8801859 | 0.85 | LMNA (0.46) | PIM1ALDH1A1KDM4EHTTTOP1 | |
| SCHEMBL8801305 | 0.84 | PIM1 (0.48) | PIM1ALDH1A1KDM4EPOLBHSP90AA1 | |
| SCHEMBL8802020 | 0.84 | CYP3A4 (0.43) | PIM1ALDH1A1KDM4EPOLBHSP90AA1 | |
| SCHEMBL8801501 | 0.83 | HPGD (0.51) | PIM1ALDH1A1KDM4EPOLBHSP90AA1 | |
| SCHEMBL8803700 | 0.83 | PIM1 (0.45) | PIM1ALDH1A1KDM4EPOLBHSP90AA1 | |
| SCHEMBL8803908 | 0.82 | ALDH1A1 (0.40) | PIM1ALDH1A1KDM4EPOLBHSP90AA1 | |
| SCHEMBL9048080 | 0.80 | ALDH1A1 (0.55) | PIM1ALDH1A1KDM4EPOLBHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612731-B1 | Novel guinolone and naphthyridone derivatives | BAYER AG (DE) | 1997-08-20 | — | — | EP | disclosed |
| EP-0612731-A1 | Novel guinolone and naphthyridone derivatives | BAYER AG (DE) | 1994-08-31 | — | — | EP | disclosed |