Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A known ✓ | Q03164 | 4/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.36 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7398720 | 0.91 | SLC2A1 (0.50) | SLC2A1MAPTALDH1A1GSK3BMEN1 | |
| SCHEMBL7354934 | 0.91 | SLC2A1 (0.56) | SLC2A1MAPTALDH1A1TP53GSK3B | |
| SCHEMBL10742386 | 0.74 | SLC2A1 (0.56) | SLC2A1MAPTALDH1A1KDM4ETP53 | |
| SCHEMBL4539804 | 0.70 | SLC2A1 (0.63) | SLC2A1MAPTALDH1A1TP53MEN1 | |
| SCHEMBL7419513 | 0.68 | SLC2A1 (0.43) | SLC2A1MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL9848234 | 0.68 | SLC2A1 (0.43) | SLC2A1MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL9602657 | 0.65 | SMN1; SMN2 (0.72) | SLC2A1MAPTALDH1A1TP53GSK3B | |
| SCHEMBL9280672 | 0.65 | SLC2A1 (0.48) | SLC2A1MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL10983954 | 0.65 | MAPT (0.61) | SLC2A1MAPTALDH1A1TP53KMT2A | |
| SCHEMBL5020108 | 0.64 | HSD17B10 (0.73) | SLC2A1MAPTALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0463877-B2 | Controlled release pharmaceutical preparation | TANABE SEIYAKU CO (JP) | 1997-07-02 | — | — | EP | disclosed |