Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.53 |
| ▸ | RAB9A | P51151 | 12/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | SCD | O00767 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11410245 | 0.83 | SCD (0.60) | NPC1RAB9ASMN1; SMN2PKMGAA | |
| SCHEMBL13522353 | 0.82 | SCD (0.52) | NPC1RAB9ASMN1; SMN2PKMGAA | |
| SCHEMBL12162598 | 0.81 | GAA (0.52) | NPC1RAB9ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL8985439 | 0.80 | SCD (0.61) | NPC1RAB9ASMN1; SMN2PKMGAA | |
| SCHEMBL23932824 | 0.79 | IL6 (0.50) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL23566353 | 0.79 | SCD (0.63) | NPC1RAB9ASMN1; SMN2PKMGAA | |
| SCHEMBL23932941 | 0.78 | HCRTR1 (0.42) | HDAC6 | |
| SCHEMBL23932773 | 0.78 | HCRTR1 (0.42) | NPC1RAB9AMAPT | |
| SCHEMBL22467975 | 0.78 | FFAR2 (0.53) | GAAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL22468097 | 0.78 | MAPT (0.47) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160296449-A1 | Semi-Permanent Hair Straightening Composition And Method | LUBRIZOL ADVANCED MATERIALS, INC. | 2016-10-13 | — | — | US | claimed |
| EP-3065831-A1 | SEMI-PERMANENT HAIR STRAIGHTENING COMPOSITION AND METHOD | Lubrizol Advanced Materials, Inc. (US) | 2016-09-14 | — | — | EP | claimed |
| EP-2826461-B1 | Method for straightening keratin fibres using a heating means and a denaturing agent | ORÉAL L (FR) | 2016-06-01 | — | — | EP | claimed |
| WO-2015069823-A1 | SEMI-PERMANENT HAIR STRAIGHTENING COMPOSITION AND METHOD | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2015-05-14 | — | — | WO | claimed |
| EP-2826461-A1 | Method for straightening keratin fibres using a heating means and a denaturing agent | L'Oréal (FR) | 2015-01-21 | — | — | EP | claimed |
| US-20100284954-A1 | PROCESS FOR RELAXING KERATIN FIBRES | L'OREAL (FR) | 2010-11-11 | — | — | US | claimed |
| EP-1351979-B1 | REGULATED ACTIVATION OF CELL-MEMBRANE RECEPTORS BY METAL-CHELATING AGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-01-16 | — | — | EP | claimed |
| EP-1032387-B1 | NOVEL METAL COMPLEXES | SMITHKLINE BEECHAM CORP (US) | 2007-03-07 | — | — | EP | claimed |
| US-20060127337-A1 | Process for relaxing keratin fibres | L'OREAL (FR) | 2006-06-15 | — | — | US | claimed |
| EP-1661551-A2 | Method of straightening keratin fibres with heating means and a denaturant agent | L'OREAL (FR) | 2006-05-31 | — | — | EP | claimed |
| WO-2023111081-A1 | PROCESS FOR DYEING KERATIN FIBRES USING A COPOLYMER BASED ON ACETOACETATE FUNCTIONS, A CROSSLINKING AGENT, A COLOURING AGENT AND A METAL COMPOUND | L'OREAL (FR) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023111079-A1 | PROCESS FOR DYEING KERATIN FIBRES USING A (CO)POLYMER BASED ON ACETOACETATE FUNCTIONS, A CROSSLINKING AGENT, A COLOURING AGENT AND A METAL COMPOUND | L'OREAL (FR) | 2023-06-22 | — | — | WO | disclosed |
| US-20230158025-A1 | GALACTOKINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH | 2023-05-25 | — | — | US | disclosed |
| US-20230158025-A1 | GALACTOKINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH | 2023-05-25 | — | — | US | disclosed |
| US-11399611-B2 | Process for straightening keratin fibres with a heating means and denaturing agents | L'OREAL (FR) | 2022-08-02 | — | — | US | disclosed |
| US-4689335-A | Heterocyclic guanidines for treating gastrointestinal motility dysfunction | WILLIAM H. RORER, INC. (US) | 1987-08-25 | — | — | US | disclosed |
| US-4347310-A | INCREASED PHOTOSENZITIVITY USING GUANIDINE DERIVTIVES AS SENSITIZERS; PHOTOSTABILITY; STORAGE STABILITY | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1982-08-31 | — | — | US | disclosed |
| US-4159898-A | Alkyl-guanidino-heterocyclic compounds, their manufacture and use as additives for fuels and lubricants | INSTITUT FRANCAIS DU PETROLE (FR) | 1979-07-03 | — | — | US | disclosed |
| US-4113637-A | DISPERSANTS, DETERGENTS | INSTITUT FRANCAIS DU PETROLE (FR) | 1978-09-12 | — | — | US | disclosed |
| US-4071459-A | Alkyl-guanidino-heterocyclic compounds, their manufacture and use as additives for fuels and lubricants | INSTITUT FRANCAIS DU PETROLE (FR) | 1978-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11399611-B2 | Process for straightening keratin fibres with a heating means and denaturing agents | KRT18, KRTCAP2, TUBB4A | NPC1 4391/4885RAB9A 4079/4885SMN1; SMN2 2504/4885 |
| US-20100284954-A1 | PROCESS FOR RELAXING KERATIN FIBRES | KRT18, TPM4, MYLK | NPC1 4849/4885RAB9A 2713/4885SMN1; SMN2 3501/4885 |
| US-20230158025-A1 | GALACTOKINASE INHIBITORS | GALK1, GCK, GCKR | NPC1 3021/4885RAB9A 2719/4885SMN1; SMN2 3570/4885 |
| US-20160296449-A1 | Semi-Permanent Hair Straightening Composition And Method | KRT18, PRKDC, DNMT1 | NPC1 4812/4885RAB9A 4673/4885SMN1; SMN2 3381/4885 |
| US-20060127337-A1 | Process for relaxing keratin fibres | KRT18, TPM4, MYLK | NPC1 4849/4885RAB9A 2713/4885SMN1; SMN2 3501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.