Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 6/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8804496 | 0.87 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| SCHEMBL8805327 | 0.85 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| SCHEMBL8804471 | 0.84 | HTR2A (0.45) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| SCHEMBL8804812 | 0.83 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| SCHEMBL8804674 | 0.82 | CARM1 (0.34) | ADRA2AADRA2BADRA2CHTR2ADRD2 | |
| SCHEMBL8803882 | 0.81 | USP2 (0.35) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| SCHEMBL9139219 | 0.79 | HTR1A (0.37) | ADRA1AHTR1AHTR2ADRD2KDM4E | |
| SCHEMBL8877192 | 0.78 | GRIN2B (0.36) | ADRA2AADRA2BADRA2CKDM4EKMT2A | |
| SCHEMBL8803688 | 0.77 | HTR1A (0.50) | ADRA2AADRA2BADRA2CADRA1AHTR1A | |
| SCHEMBL11867042 | 0.77 | HTR1A (0.52) | ADRA2AADRA2BADRA2CADRA1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647231-B1 | N-SUBSTITUTED 3-AZABICYCLO[3.2.0]HEPTANE DERIVATIVES USEFUL AS NEUROLEPTIC AGENTS, ETC. | BASF AG (DE) | 1997-08-27 | — | — | EP | disclosed |
| US-5475105-A | N-substituted azabicycloheptane derivatives | BASF AKTIENGESELLSCHAFT (DE) | 1995-12-12 | — | — | US | disclosed |