Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.49 |
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 4/20 | 0.37 |
| ▸ | CTSB | P07858 | 3/20 | 0.37 |
| ▸ | CTSS | P25774 | 3/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813467 | 0.84 | FFAR1 (0.44) | CTSLCTSBCTSSCTSKFFAR1 | |
| SCHEMBL2317 | 0.81 | FFAR1 (0.48) | CTSLCTSBCTSSCTSKFFAR1 | |
| SCHEMBL14004740 | 0.81 | FFAR1 (0.48) | CTSLCTSBCTSSCTSKFFAR1 | |
| SCHEMBL8808708 | 0.81 | CTSL (0.37) | MEN1KMT2ACTSLCTSBCTSS | |
| Hydrochloric Acid SCHEMBL3473569 | 0.80 | FFAR1 (0.47) | CTSLCTSBCTSSCTSKFFAR1 | |
| SCHEMBL2437416 | 0.80 | CTSS (0.42) | CTSLCTSBCTSSCTSKTRPM8 | |
| Hydrochloric Acid SCHEMBL2728 | 0.80 | FFAR1 (0.47) | CTSLCTSBCTSSCTSKFFAR1 | |
| Hydrochloric Acid SCHEMBL3412065 | 0.80 | CTSB (0.41) | CTSLCTSBCTSSCTSKTRPM8 | |
| SCHEMBL8483362 | 0.78 | AGTR1 (0.41) | MAOAMAOBFFAR1 | |
| SCHEMBL7440252 | 0.76 | MAOB (0.46) | MAOAMAOBFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528762-B1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0528762-A1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA-GEIGY AG (CH) | 1993-02-24 | — | — | EP | disclosed |